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Cat. Number
H62540
Chemical Name
H62540 C8 Ceramide (d18:1/8:0) 74713-59-0
CAS Number
74713-59-0
Category
Glycerols, Fatty Acid Derivatives & Lipids; Inhibitors; Activators; Protein Kinase Inhibitors and Activators
Mol. Formula
C26H51NO3
Mol. Weight
425.7
Qty 1
10mg
Qty 2
25mg
Appearance
A crystalline solid
Application Notes
≥98%
Synonym
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide;C8;Ceramide Ceramide (d18:1/8:0);Cer(d18:1/8:0);N-octanoyl-D-erythro-Sphingosine N-Octanoylsphingosine
Solubility
acidic PBS: <50 µg/ml;DMSO: >20 mg/ml;Ethanol: >33 mg/ml;PBS pH 7.2: <50 µg/ml
Storage condition
-20°C
Stability
≥ 1 year
References

C8 Ceramide (d18:1/8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels.1 For this reason, treatment of cells with C8 ceramide (d18:1/8:0) may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C8 Ceramide (d18:1/8:0) likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes2 and induces apoptosis of both human leukemia cells and the U937 cell line.1,3

神经酰胺是由神经鞘氨醇长链碱基与脂肪酸组成神经鞘氨脂质一种。神经酰胺(Ceramide)是以神经酰胺为骨架的一类磷脂,主要有神经酰胺磷酸胆碱和神经酰胺磷酸乙醇胺,磷脂是细胞膜的主要成分,神经酰胺(Ceramides, Cers)存在于所有的真核细胞中,对细胞分化、增殖、凋亡、衰老等生命活动具有重要调节作用。

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C2 Ceramide (d18:1/2:0)

C6 Ceramide (d18:1/6:0)

C8 Ceramide (d18:1/8:0)

C16 Ceramide (d18:1/16:0)

C16 Ceramide (d18:1(14Z)/16:0)

C18 Ceramide (d18:1/18:0)

C22 Ceramide (d18:1(14Z)/22:0)

C22:1 Ceramide (d18:1(14Z)/22:1(13Z))

C24 Ceramide (d18:1/24:0)

C24 Ceramide (d18:1(14Z)/24:0)

C6 Ceramide-d7 (d18:1-d7/6:0)

C16 Ceramide-d7 (d18:1-d7/16:0)

C18 Ceramide-d7 (d18:1-d7/18:0)

C24 Ceramide-d7 (d18:1-d7/24:0)

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))



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