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Cat. Number
H62525
Chemical Name
H62525 C6 Ceramide (d18:1/6:0) 124753-97-5
CAS Number
124753-97-5
Category
Fatty Acid Derivatives & Lipids; Glycerols, Inhibitors, Isotope Labelled Compounds, Protein Kinase Inhibitors and Activators
Mol. Formula
C24H47NO3
Mol. Weight
397.6
Qty 1
5mg
Qty 2
10mg
Appearance
Off-White Solid
Application Notes
≥98%
Synonym
N-Caproyl-C18-sphingosine;Cer(18:1/6:0);Ceramide (d18:1/6:0) ;C6 Ceramide N-hexanoyl-D-erythro-sphingosine
Melting Pt.
69-72°C
Solubility
DMF: >22 mg/ml DMSO: >20 mg/ml
Storage condition
-20°C Freezer
Stability
≥ 1 year
References

C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides.1 C6 ceramide mediates many diverse biological activities including apoptosis,2 activation of protein phosphatase 2A,1,3 and inhibition of the mitochondrial respiratory chain.4 It also enhances the expression of COX-2 in rat granulosa cells5 and stimulates the growth of bovine aortic smooth muscle cells.6 C6 ceramide acts in neuronal axons to inhibit neurite growth.7


神经酰胺是由神经鞘氨醇长链碱基与脂肪酸组成神经鞘氨脂质一种。神经酰胺(Ceramide)是以神经酰胺为骨架的一类磷脂,主要有神经酰胺磷酸胆碱和神经酰胺磷酸乙醇胺,磷脂是细胞膜的主要成分,神经酰胺(Ceramides, Cers)存在于所有的真核细胞中,对细胞分化、增殖、凋亡、衰老等生命活动具有重要调节作用。

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C2 Ceramide (d18:1/2:0)

C6 Ceramide (d18:1/6:0)

C8 Ceramide (d18:1/8:0)

C16 Ceramide (d18:1/16:0)

C16 Ceramide (d18:1(14Z)/16:0)

C18 Ceramide (d18:1/18:0)

C22 Ceramide (d18:1(14Z)/22:0)

C22:1 Ceramide (d18:1(14Z)/22:1(13Z))

C24 Ceramide (d18:1/24:0)

C24 Ceramide (d18:1(14Z)/24:0)

C6 Ceramide-d7 (d18:1-d7/6:0)

C16 Ceramide-d7 (d18:1-d7/16:0)

C18 Ceramide-d7 (d18:1-d7/18:0)

C24 Ceramide-d7 (d18:1-d7/24:0)

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))



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