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ADC药物解决方案
Chemical Name
Sigma Merk ADC药物解决方案——偶联试剂&连接子
References

抗体药物偶联物简称ADC(antibody-drug conjugate,ADC).抗体药物偶联物(antibody-drug conjugate,ADC)是通过一个化学链将具有生物活性的小分子药物连接到单抗上,单抗作为载体将小分子药物靶向运输到目标细胞中。在ADC药物研发生产过程中,从单抗制备,选择合适连接子到偶联反应,以及后续质检分析,选择合适的试剂、工具、服务和技术都至关重要。默克在这些关键步骤都能提供优质的解决方案,助力客户更快地推进ADC药物的开发进程。


试剂类别  产品货号     说明
氧化/还原剂TCEP75259PBioUltra
DL-二硫苏糖醇43815BioUltra
NaBH3CN15615995%
(L)-脱氢抗坏血酸    261556Powder
淬灭剂 N-乙酰基-L-半胱氨酸 A8199A8199
L-半胱氨酸 盐酸盐 一水合物 C6852meets EP, USP testing specifications
缓冲溶液L -精氨酸 单盐酸盐 A5131≥98% (HPLC)
L-组氨酸 53319BioUltra, ≥99.5% (NT)
溶剂DMA271012anhydrous, 99.8%
 38840puriss. p.a., ≥99.5% (GC)
17308≥99.8% (GC)
DMSO276855anhydrous, ≥99.9%
41640puriss. p.a., ACS reagent, ≥99.9% (GC)
D1436meets EP testing specifications, meets USP testing specifications
DMF227056anhydrous, 99.8%
33120puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

ADC药物解决方案连接子


在ADC药物研发生产过程中,从单抗制备,选择合适连接子到偶联反应,以及后续质检分析,选择合适的试剂、工具、服务和技术都至关重要。默克在这些关键步骤都能提供优质的解决方案,助力客户更快地推进ADC药物的开发进程。

货号名称CAS
413142-Maleimidoethyl   mesylate, technical, ≥90.0%   (HPLC)
M27863-Maleimidobenzoic   acid N-hydroxysuccinimide ester, crystalline58626-38-3
QBD100754-formyl-benzamido-dPEG®  12-EDA-MAL
5686006-Maleimidohexanoic   acid N-hydroxysuccinimide ester, 98%55750-63-5
QBD10127Acid-dPEG®  13-NHS ester
QBD10109Acid-dPEG®  5-NHS ester
QBD10119Acid-dPEG®   9-NHS ester
764205Alkyne-PEG4-maleimide,   90% (HPLC)
QBD10505Azido-dPEG®  12-NHS ester
QBD10501Azido-dPEG®   4-NHS ester
QBD10503Azido-dPEG®   8-NHS ester
QBD10195Biotin-dPEG®  11-MAL
QBD10785Biotin-dPEG®   23-MAL
QBD10201Biotin-dPEG®   3-MAL
803537Bis(NHS)PEG5756526-03-1
QBD10954Bis-dPEG®  13-NHS ester1008402-79-6
QBD10397Bis-MAL-dPEG®  11854753-78-9
QBD10215Bis-MAL-dPEG®  3
QBD10631Bis-MAL-Lysine-dPEG®  4-TFP ester
QBD10593DBCO-dPEG®  12-MAL
QBD10594DBCO-dPEG®  24-MAL
760668Dibenzocyclooctyne-maleimide,   for Copper-free Click Chemistry
760676Dibenzocyclooctyne-PEG4-maleimide,   for Copper-free Click Chemistry
QBD11170DOTA   tris(TBE)-amido-dPEG®  23-Maleimide
QBD11167DOTA-tris(acid)-amido-dPEG®  11-Maleimide
QBD11171DOTA-tris(acid)-amido-dPEG®  23-Maleimide
QBD11166DOTA-tris(TBE)-amido   dPEG®  11-Maleimide
QBD10852dPEG®  12-SATA (S-acetyl-dPEG®  12-NHS ester)1334169-95-7
QBD10181dPEG®  4-SATA (S-acetyl-dPEG®  4-NHS ester)937025-17-7
QBD10184dPEG®  8-SATA (S-acetyl-dPEG®  8-NHS ester)1070798-99-0
803677EMCH   (N-(ε-maleimidocaproic acid) hydrazide, trifluoroacetic acid salt)
QBD10996Fmoc-N-amido-dPEG®  12-NHS ester488085-18-3
QBD10994Fmoc-N-amido-dPEG®  4-NHS ester1314378-14-7
QBD10995Fmoc-N-amido-dPEG®  8-NHS ester1334170-03-4
803421LC-SDA   (NHS-LC-Diazirine) (succinimidyl 6-(4,4′-azipentanamido)
    hexanoate)

803383LC-SMCC   (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-car-
    boxy-(6-amidocaproate))

QBD11028MAL-dPEG®  12-DSPE
QBD11388Mal-dPEG®   24-amido-dPEG® 24-amido-dPEG® 24-DSPE
QBD11093MAL-dPEG®   24-amido-dPEG® 24-DSPE
QBD11303MAL-dPEG®   24-amido-dPEG® 24-TFP ester
QBD10555MAL-dPEG®   36-TFP ester
QBD10819MAL-dPEG®  11-Lipoamide1334172-73-4
QBD10553MAL-dPEG®  12-TFP ester
QBD10314MAL-dPEG®   24-NHS ester
QBD10554MAL-dPEG®   24-TFP ester
QBD10406MAL-dPEG®   4-(m-dPEG®  12)31334178-05-0
QBD10551MAL-dPEG®   4-TFP ester
QBD10552MAL-dPEG®   8-TFP ester
746215Maleimide-PEG12-succinimidyl   ester1426151-00-9
746223Maleimide-PEG2-succinimidyl   ester, ≥95%955094-26-5
746193Maleimide-PEG6-succinimidyl   ester1137109-21-7
746207Maleimide-PEG8-succinimidyl   ester756525-93-6
QBD11086m-dPEG®  13-NHS ester
QBD10289m-dPEG®  12-MAL88504-24-9
QBD10262m-dPEG®  12-NHS ester
QBD10319m-dPEG®   24-MAL
QBD10304m-dPEG®  24-NHS ester
QBD10745m-dPEG®  4-MAL1263044-81-0
QBD10211m-dPEG®  4-NHS ester622405-78-1
QBD10746m-dPEG®  8-MAL1334169-90-2
QBD10260m-dPEG®  8-NHS ester756525-90-3
900914Methyltetrazine-NHS   ester, ≥95%1644644-96-1
56951N-(2-Aminoethyl)maleimide   trifluoroacetate salt, ≥95%   (HPLC), ≥98% (T)146474-00-2
773263N-(2-Hydroxyethyl)maleimide,   97%1585-90-6
QBD10198NHS-dPEG®  12-biotin
QBD10774NHS-dPEG®  24-biotin
QBD10401NHS-dPEG®  4-(m-dPEG®    12)3-ester1334178-03-8
QBD10200NHS-dPEG®  4-biotin459426-22-3
QBD10194NHS-S-S-dPEG®  4-biotin (cleavable)1260247-51-5
689777O-[N-(3-Maleimidopropionyl)aminoethyl]-O′-[3-(N-succinimidy-
    loxy)-3-oxopropyl]heptacosaethylene glycol, ≥90% (oligomer purity)

712582O-[N-(3-Maleimidopropionyl)aminoethyl]-O′-[3-(N-succinimidy-
    loxy)-3-oxopropyl]triethylene glycol, ≥90% (NMR)
756525-99-2
901767PC   biotin-PEG3-NHS ester2353409-93-3
QBD11135Phthalimidooxy-dPEG®  12-NHS ester
QBD10011Phthalimidooxy-dPEG®  4-NHS ester
803413SDA   (NHS-Diazirine) (succinimidyl 4,4′-azipentanoate)
803626SMPH   (succinimidyl-6-((b-maleimidopropionamido)hexanoate)367927-39-7
QBD10378SPDP-dPEG®  12-NHS ester924280-65-9
QBD10374 SPDP-dPEG® 4-NHS ester1334177-95-5
QBD10376SPDP-dPEG®   8-NHS ester1252257-56-9
803359Sulfo-LC-SDA   (Sulfo-NHS-LC-Diazirine) (sulfosuccinimidyl
    6-(4,4′-azipentanamido)hexanoate)

803340Sulfo-SDA   (Sulfo-NHS-Diazirine) (sulfosuccinimidyl 4,4′-azipentanoate)
803243Sulfo-SMPB   (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)
QBD11435Tetra(-amido-dPEG®  11-MAL)pentaerythritol
QBD11414Tetra(-amido-dPEG®   23-MAL)pentaerythritol
CF0041Urea   crosslinker – C4-arm, NHS ester (DSBU, BuUrBU)1240387-33-0

货号
  产品描述
规格
10771-100MLHistopaque®-10776X100ML
10771-500ML
Histopaque®-1077
500 mL
10771-6X100MLHistopaque®-10776X100ML
11191-100MLHistopaque®-1119100ML
11191-6X100MLHistopaque®-11196X100ML
A2220-10MLNTI-FLAG® M2 Affinity   Gel10 mL
A2220-4X25MLNTI-FLAG® M2 Affinity   Gel10 mL
A2220-5MLNTI-FLAG® M2 Affinity   Gel5 mL
A222-25MLNTI-FLAG® M2 Affinity   Gel10 mL
A5486-100MGAzoxymethane100 mg
A5486-25MGAzoxymethane25 mg
A5503-1GAlbumin from chicken   egg white1 g
A6964-500MLAccutase® solution500 mL
C0130-1GCollagenase from   Clostridium histolyticum1g
C5138-1GCollagenase from   Clostridium histolyticum1 g
C5138-500MGCollagenase from   Clostridium histolyticum500 mg
D1556-250MLOptiPrep™ Density   Gradient Medium250 mL
D2650-100MLDimethyl sulfoxide100 mL
D4540-100MLDimethyl sulfoxide100 mL
D4693-1GDispase® II1 g
D9542-10MGDAPI for nucleic acid   staining10mg
D9542-5MGDAPI for nucleic acid   staining5mg
DUO92008-30RXNDuolink® In Situ   Detection Reagents Red30 reactions
F1804-1MGAnti-FLAG M2 Antibody   produced in mouse1 mg
F1804-200UGAnti-FLAG M2 Antibody   produced in mouse200 μg
F1804-50UGAnti-FLAG M2 Antibody   produced in mouse50 μg
F3165-.2MGMonoclonal ANTI-FLAG®   M2 antibody produced in mouse.2MG
F5506-10MLFreund’s Adjuvant,   Incomplete10ML
F5506-10X10ML
   
Freund’s Adjuvant,   Incomplete10X10ML
F5881-10MLFreund’s Adjuvant,   Complete10ML
F5881-10X10MLFreund’s Adjuvant,   Complete10X10ML
H4034-1KGHEPES1 kg
L2630-100MGLipopolysaccharides   from Escherichia coli O111:B4100 mg
L2630-10MGLipopolysaccharides   from Escherichia coli O111:B410mg
L2630-25MGLipopolysaccharides   from Escherichia coli25 mg
L4391-1MGLipopolysaccharides   from Escherichia coli O111:B41 mg
M3148-250ML2-Mercaptoethanol250mL
M8823-1MLAnti-FLAG® M2   Magnetic Beads1 mL
M8823-5MLAnti-FLAG® M2   Magnetic Beads5 mL
P1585-1MGPMA1 mg
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