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| Cat. Number | T286163 |
| Chemical Name | T286163 THEAFLAVIN-3,3’-DIGALLATE 30462-35-2 |
| CAS Number | 30462-35-2 |
| Mol. Formula | C43H32O20 |
| Mol. Weight | 868.71 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | Brick red powder |
| Application Notes | ≥98% |
| Synonym | Theaflavin digallate |
| Melting Pt. | 226-230°C dec |
| Solubility | 0.1 mg/mL water. |
| Storage condition | 4°C |
| References | Theaflavin-3,3’-digallate is a polyphenolic compound found in black tea. The theaflavins are formed during the enzymatic oxidation of catechins, which happens during processing of the fresh tea leaves. Theaflavin-3,3’-digallate has also shown inhibitory effects on ovarian cancer cells OVCAR-3 and A2780/CP70 by inducing apoptosis and impairing tumor angiogenesis. In addition, theaflavin-3,3’-digallate was found to produce notably efficient reactive oxygen species scavenging activity by a chemiluminescence assay. Theaflavin-3,3’-digallate was also shown to produce chemopreventive effects through the inhibition of the EGFR signaling pathway as a result of EGFR down-regulation. ReferencesGao Y, Rankin GO, Tu Y, et al. Inhibitory effects of the four main theaflavin derivatives found in black tea on ovarian cancer cells. Anticancer Res. 2016 Feb;36(2):643-651. PMID: 26851019. Wu YY, Li W, Xu Y, et al. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence adn DNA damage analyses. J Zhejiang Univ Sci B. 2011 Sep;12(9):744-751. PMID: 21887850. Mizuno H, Cho YY, Zhu F, et al. Theaflavin-3,-3’-digallate induces epidermal growth factor receptor downregulation. Mol Carcinog. 2006 Mar;45(3):204-212. PMID: 16353237. |
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