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| Cat. Number | B1855 |
| Chemical Name | B1855 O6-BENZYLGUANINE 19916-73-5 |
| CAS Number | 19916-73-5 |
| Mol. Formula | C12H11N5O |
| Mol. Weight | 241.25 |
| Qty 1 |
50mg |
| Qty 2 | 1g |
| Appearance | White Powder |
| Application Notes | ≥98% |
| Storage condition | Ambient |
| References | O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine often used to examine DNA repair mechanisms. O6-BG acts as an inhibitor of O6-methylguanine DNA methyltransferase (MGMT), an enzyme that repairs damage to guanine residues in DNA. As many alkylating and cross-linking chemotherapeutics act on guanine residues to induce DNA damage in cancer cells, O6-BG prevents the repair of the damaged DNA, allowing apoptosis and other mechanisms of cell death to occur. In animals and humans, O6-BG shows some benefit in improving efficacy of co-administered treatments, potentially increasing survival time. This compound is currently in clinical trials examining its anticancer chemotherapeutic potential. ReferencesQian L, Zheng J, Wang K, et al. Cationic core-shell nanoparticles with carmustine contained within O6-benzylguanine shell for glioma therapy. Biomaterials. 2013 Nov;34(35):8968-78. PMID: 23953782. Quinn JA, Jiang SX, Reardon DA, et al. Phase II trial of temozolomide plus O6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7. PMID: 19204199. Quinn JA, Jiang SX, Carter J, et al. Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Clin Cancer Res. 2009 Feb 1;15(3):1064-8. PMID: 19188181. Friedman HS, Keir S, Pegg AE, et al. O6-benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther. 2002 Sep;1(11):943-8. PMID: 12481416. Friedman HS, Pluda J, Quinn JA, et al. Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2000 Oct 15;18(20):3522-8. PMID: 11032594. |
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