服务热线
021-60498804
| Cat. Number | B3573 |
| Chemical Name | B3573 BISDEMETHOXYCURCUMIN 24939-16-0 |
| CAS Number | 24939-16-0 |
| Mol. Formula | C19H16O4 |
| Mol. Weight | 308.33 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | orange powder |
| Application Notes | ≥98% |
| Solubility | DMSO |
| Storage condition | Ambient |
| References | Bisdemethoxycurcumin, like its parent compound curcumin, exhibits anticancer, antioxidative, anti-diabetic, anti-inflammatory, and antibacterial activities. Bisdemethoxycurcumin inhibits Wnt signaling by inhibiting WIF-1 promoter demethylation and inhibits DNA methyltransferase 1 (DNMT1), inducing apoptosis in non-small cell lung cancer (NSCLC) cells. Bisdemethoxycurcumin also induces apoptosis in other in vitro cancer models through increases in reactive oxygen species (ROS) and increases in the expression of p53, p21, p16, and retinoblastoma (Rb) protein. This compound activates SIRT1 and AMPK signaling. Bisdemethoxycurcumin inhibits PDGF signaling in smooth muscle cells, preventing cell migration and proliferation. Bisdemethoxycurcumin may also display potential benefit in the treatment of type 2 diabetes, as it acts as a noncompetitive inhibitor of pancreatic α-amylase. Like other curcuminoids, this compound also displays phototoxic antibacterial activity, although it is active primarily against gram-positive bacteria only. ReferencesLi YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830. Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593. Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078. Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852. Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103. Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com |
下一个：没有了上一个：AICAR |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
