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| Cat. Number | 10-2828 |
| Chemical Name | 10-2828 N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide 219766-25-3 |
| CAS Number | 219766-25-3 |
| Mol. Formula | C22H21N3O3S |
| Mol. Weight | 407.49 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide |
| Solubility | Soluble in DMSO (up to 20 mg/ml). |
| Storage condition | -20°C (des.) |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| References | ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. ANA-12 displays antidepressant and anxiolytic properties in mouse models after systemic administration.1 Shows antidepressant effects on LPS-induced depression-like behavior in mice.2 ANA-12 has been used to elucidate the role of BDNF in improvement of cognitive decline during calorie restriction3 and in the discovery of new neurotrophic agents4.
References/Citations
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