您的位置:首页>>生化试剂>>小分子化合物>>10-2828 N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide 219766-25-3
Cat. Number
10-2828
Chemical Name
10-2828 N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide 219766-25-3
CAS Number
219766-25-3
Mol. Formula
C22H21N3O3S
Mol. Weight
407.49
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Solubility
Soluble in DMSO (up to 20 mg/ml).
Storage condition
-20°C (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
References

ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. ANA-12 displays antidepressant and anxiolytic properties in mouse models after systemic administration.1 Shows antidepressant effects on LPS-induced depression-like behavior in mice.2 ANA-12 has been used to elucidate the role of BDNF in improvement of cognitive decline during calorie restriction3 and in the discovery of new neurotrophic agents4.

References/Citations
1) Cazorla et al. (2011), Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice; J. Clin. Invest., 121 1846
2) Zhang et al. (2014), Antidepressant effects of TRKB ligands on depression-like behavior and dendritic changes in mice after inflammation; J. Neuropsychopharmacol., 18 pyu077
3) Kishi et al. (2015), Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus of obesity-induced hypertensive rats; Int. Heart J., 56 110
4) Chakravarty et al. (2015) A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action; Sci. Rep., 5 14134

Image 1

ANA-12 ,货号10-2828 上海惠诚提供5mg 25mg ANA-12,美国focus原装进口,咨询电话021-60498804

下一个:PD173074上一个:DMAPT
在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们