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Cat. Number
10-2825
Chemical Name
10-2825 Dimethylamino-parthenolide 870677-05-7
CAS Number
870677-05-7
Mol. Formula
C17H27NO3
Mol. Weight
293.41
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
99% by HPLC NMR (Conforms)
Synonym
Dimethylamino-parthenolide
Solubility
Soluble in DMSO, Ethyl acetate, or Ethanol.
Storage condition
-20°C (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
References

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK1. In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair2.

References/Citations
1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer, 128 2481
2) Estrabrook et al. (2011), Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249

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