您的位置:首页>>生化试剂>>小分子化合物>>10-2672 (3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one 58-46-8
Cat. Number
10-2672
Chemical Name
10-2672 (3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one 58-46-8
CAS Number
58-46-8
Mol. Formula
C19H27NO3
Mol. Weight
317.43
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Storage condition
RT (des.)
Stability
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).
References

Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.4.

References/Citations
1) Scherman et al. (1983), Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine; Proc. Natl. Acad. Sci. USA, 80 584
2) Peter et al. (1996), Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine; J. Biol. Chem., 271 2979
3) Schafer et al. (2013), Localization and expression of VMAT2 across mammalian species: a translational guide for it's visualization and targeting in health and disease; Adv. Pharmacol., 68 319
4) Sakano et al. (2014), VMAT2 identified as a regulator of late-stage β-cell differentiation; Nat. Chem. Biol., 10 141

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丁苯那  英文名称Tetrabenazine ,货号10-2672 上海惠诚提供10mg 50mg 丁苯那 Tetrabenazine,美国focus原装进口,咨询电话021-60498804

丁苯那  英文名称Tetrabenazine ,货号10-2672 上海惠诚提供10mg 50mg 丁苯那 Tetrabenazine,美国focus原装进口,咨询电话021-60498804

 

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