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Cat. Number
10-2654
Chemical Name
from Streptomyces albus
CAS Number
55721-31-8
Mol. Formula
C42H69O11 Na
Mol. Weight
772.98
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
97% by TLC NMR (Conforms)
Solubility
Soluble in DMSO.
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1 Salinomycin Na displays selective toxicity for cancer stem cells.1 Induces rapid mitochondrial hyperpolarization.2 Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3 Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5

References/Citations
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2)1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., epub. ahead of print.

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