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| Cat. Number | 10-2618 |
| Chemical Name | 10-2618 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane 1675-54-3 |
| CAS Number | 1675-54-3 |
| Mol. Formula | C21H24O4 |
| Mol. Weight | 340.41 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | White low melting point solid |
| Application Notes | 95% by HPLC NMR (Conforms) |
| Synonym | Bisphenol A diglycidyl ether |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| References | BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo. References/Citations
1) Cuzzocrea et al. (2004), Rosiglitazone , a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation; Eur. J. Pharmacol., 483 79
BADGE ，货号10-2618上海惠诚提供10mg 50mg BADGE，美国focus原装进口，咨询电话021-60498804 BADGE ，货号10-2618上海惠诚提供10mg 50mg BADGE，美国focus原装进口，咨询电话021-60498804
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