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Cat. Number
10-2570
Chemical Name
10-2570 22-Oxovincaleukoblastine sulfate 2068-78-2
CAS Number
2068-78-2
Mol. Formula
C46H56N4O10
Mol. Weight
923.06
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Leurocristine sulfate
Solubility
Soluble in Water (up to 80 mg/ml).
Storage condition
-20°C (des.)
Stability
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
References

Vincristine sulfate (2068-78-2) arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins.1,2 Induces apoptosis.3 Vincristine sulfate is a clinically useful cancer chemotherapeutic agent.

References/Citations
1) Jordan et al. (1998), Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle; Med. Res. Rev., 18 259
2) Lobert et al. (1996), Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine; Biochemistry, 35 6806
3) Wang et al. (1999), The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review: Cancer Chemother. Pharmacol., 44 355

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