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| Cat. Number | 10-2524 |
| Chemical Name | 10-2524 6-Nitrobenzo[b]thiophene 1,1-dioxide 19983-44-9 |
| CAS Number | 19983-44-9 |
| Mol. Formula | C8H5NO4S |
| Mol. Weight | 211.2 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | Light yellow solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 6-Nitrobenzo[b]thiophene 1,1-dioxide |
| Solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml). |
| Storage condition | -20°C (des.) |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| References | Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT32. Exhibits potent antitumor activity3. Protects against angiotensin II-induced vascular dysfunction and hypertension4. Stattic is an extremely useful tool to probe involvement of STAT3 in cellular signaling.
References/Citations
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