您的位置:首页>>生化试剂>>小分子化合物>>10-2443 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide 301836-41-9
Cat. Number
10-2443
Chemical Name
10-2443 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide 301836-41-9
CAS Number
301836-41-9
Mol. Formula
C22H16N4O3
Mol. Weight
384.4
Qty 1
5mg
Qty 2
25mg
Appearance
Yellow solid
Application Notes
99% by HPLC NMR (Conforms)
Synonym
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Solubility
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

SB-431542 (301836-41-9) is a potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM)1,2. Inhibits TGFβ-induced proliferation of human osteosarcoma cells3. Ehances growth and integrity of embryonic stem cell-derived endothelial cells4. SB-431542 is a frequently used agent employed in numerous stem cell differentiation protocols5. Cell permeable.

References/Citations
1) Laping et al. (2002), Inhibition of transforming growth factor (TGF-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I kinase activity: SB-431542; Mol. Pharmacol., 6258
2) Inman et al. (2002), SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5 and ALK7; Mol. Pharmacol., 62 65
3) Matsuyama et al. (2003), SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells; Cancer Res., 63 7791
4) Watabe et al. (2003), TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells; J. Cell Biol., 163 1303
5) Stanslowsky et al. (2014), Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells; Stem Cell Res. Ther., 5 35

Image 1

SB-431542,货号10-2443 上海惠诚提供5mg 25mgSB-431542,美国focus原装进口,咨询电话021-60498804

在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们