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| Cat. Number | 10-2377 |
| Chemical Name | 10-2377 (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 20069-09-4 |
| CAS Number | 20069-09-4 |
| Mol. Formula | C17H19NO5 |
| Mol. Weight | 317.34 |
| Qty 1 |
20mg |
| Qty 2 | 100mg |
| Appearance | Cream-colored solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| Storage condition | RT |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References | Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity2. Piperlongumine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice1. Elevation of ROS levels in response to piperlongumine may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.3
References/Citations
Piperlongumine ，货号10-2377 上海惠诚提供20mg 100mg Piperlongumine，美国focus原装进口，咨询电话021-60498804 |
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