您的位置:首页>>生化试剂>>小分子化合物>>10-2377 (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 20069-09-4
Cat. Number
10-2377
Chemical Name
10-2377 (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 20069-09-4
CAS Number
20069-09-4
Mol. Formula
C17H19NO5
Mol. Weight
317.34
Qty 1
20mg
Qty 2
100mg
Appearance
Cream-colored solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
Solubility
Soluble in DMSO (up to 25 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity2. Piperlongumine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice1. Elevation of ROS levels in response to piperlongumine may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.3

References/Citations
1) Raj et al. (2011), Selective killing of cancer cells by a small molecule targeting the stress response to ROS; Nature, 475 7355
2) Adams et al. (2012), Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs; Proc. Natl. Acad. Sci. USA, 109 15115
3) Jarvius et al. (2013), Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells; Biochem. Biophys. Res. Commun. 10.1016

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