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Cat. Number
10-2365
Chemical Name
10-2365 罗米地 Romidepsin 128517-07-7
CAS Number
128517-07-7
Mol. Formula
C24H36N4O6S2
Mol. Weight
540.71
Qty 1
1mg
Qty 2
5mg
Appearance
Colorless waxy solid
Application Notes
98% by HPLC NMR (Conforms)
Synonym
FK228, FR901228, Depsipeptide
Solubility
Soluble in DMSO (up to 10 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
References

Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Romidepsin was recently approved for clinical use in T-cell lymphoma.4

References/Citations
1) Furumai et al. (2002), FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases; Cancer Res., 62 4916
2) Panicker et al. (2010), Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells; Cell Cycle, 9 1830
3) Ueda et al. (1994), FR901228, a novel anti-tumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice; J. Antibiot. (Tokyo), 47 315
4) VanderMolin et al. (2011), Romodepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma; J. Antibiotic. (Tokyo), 64 525

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