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| Cat. Number | 10-2346 |
| Chemical Name | 10-2346 3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl 41100-52-1 |
| CAS Number | 41100-52-1 |
| Mol. Formula | C12H21N • HCl |
| Mol. Weight | 215.76 |
| Qty 1 |
50mg |
| Qty 2 | 250mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl |
| Solubility | Soluble in Water (up to 20 mg/ml) |
| Storage condition | RT (des.) |
| Stability | Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
| References | An NMDA noncompetitive, low affinity, open channel blocker, IC50~1 mM at -60 mV in rat retinal ganglion cells.1 Displays neuroprotective effects in excitotoxic conditions.2 Preferentially blocks excessive NMDA receptor activity without disrupting normal activity.3 A clinically well tolerated drug with therapeutic potential in numerous CNS degenerative disorders.4 In clinical use for Alzheimer’s disease.5 References/Citations
1) Chen and Lipton (1997), Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism; J. Physiol. 499 27
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