您的位置:首页>>生化试剂>>小分子化合物>>10-2314 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone 129722-12-9
Cat. Number
10-2314
Chemical Name
10-2314 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone 129722-12-9
CAS Number
129722-12-9
Mol. Formula
C23H27Cl2N3O2
Mol. Weight
448.4
Qty 1
20mg
Qty 2
100mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
OPC-14597
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease.3 Aripiprazole blocked cocaine-seeking behavior without affecting other rewarding behaviors in animal models.4

References/Citations
1) Green et al. (2004), Focus on aripiprazole; Curr. Med. Res. Opin., 20 207
2) Kikuchi et al. (1995), 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity; J. Pharmacol. Exp. Ther., 274 329
3) Madhusoodanan et al. (2008), Management of psychosis in patients with Alzheimer's isease: focus on aripiprazole; Clin. Interv. Aging, 3 491
4) Feltenstein et al. (2007), Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse; Biol. Psychiatry, 61 582

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