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Cat. Number
10-2199
Chemical Name
10-2199 Ansamitocin P3 66547-09-9
CAS Number
66547-09-9
Mol. Formula
C32H43ClN2O9
Mol. Weight
635.16
Qty 1
1mg
Qty 2
5mg
Appearance
White solid
Application Notes
>90% by TLC, remainder is P-1, P-2 and P-4. NMR (Conforms)
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
Storage condition
-20°C (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
References

Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines.2,3 Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization.4

References/Citations
1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722
2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding Tubulin at the Vinblastine Site; PLoS ONE 8 e75182
3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia, 46 117
4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707

Focus Biomolecules supplier, chemical structure of Ansamitocin P3 | Microtubule depolymerizer | CAS 66547-09-9

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