您的位置:首页>>生化试剂>>小分子化合物>>10-2186 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione 568-72-9
Cat. Number
10-2186
Chemical Name
10-2186 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione 568-72-9
CAS Number
568-72-9
Mol. Formula
C19H18O3
Mol. Weight
294.35
Qty 1
5mg
Qty 2
25mg
Appearance
Orange solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Storage condition
-20°C
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

Tanshinone IIA (568-72-9) is a diterpenoid naphthoquinone found in Salvia sp. and isolated as an active component of the traditional Chinese medicine Tanshen. Tanshinone IIA displays anti-inflammatory activity1 and induces apoptosis in a variety of cell lines2. Also inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50 = 0.22 μM)3.

References/Citations
1) Kang et al. (2000), Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza; Immunopharmacology, 49 355
2) Sung et al. (1999), Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3; Exp. Mol. Med., 31 174
3) Park et al. (1999), Suppression of AP-1 Activity by Tanshinone and Cancer Cell Growth Inhibition; Bull. Korean Chem. Soc., 20 925

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