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| Cat. Number | 10-2178 |
| Chemical Name | Tozasertib |
| CAS Number | 639089-54-6 |
| Mol. Formula | C23H28N8OS |
| Mol. Weight | 464.59 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | Off-white solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | VX-680, MK-0457 |
| Solubility | Soluble in DMSO (up to 100 mg/ml). |
| Storage condition | -20℃ |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References |
Tozasertib (639089-54-6) is an inhibitor of Aurora kinases.1 Blocks cell cycle progressing, inhibits proliferation, and induces apoptosis in a wide range of cancer cell lines (IC50 <10 μM for clear cell renal carcinoma).2,3
1) Harrington et al. (2004), VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo; Nat. Med., 10 262
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