您的位置:首页>>生化试剂>>小分子化合物>>10-2159 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 167869-21-8
Cat. Number
10-2159
Chemical Name
10-2159 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 167869-21-8
CAS Number
167869-21-8
Mol. Formula
C16H13NO3
Mol. Weight
267.29
Qty 1
5mg
Qty 2
25mg
Appearance
Yellow solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
2'-Amino-3'-methoxyflavone
Solubility
Soluble in DMSO (up to 6 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

PD-98059 (167869-21-8) is an inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM).1,2 PD-98059 accelerates differentiation of RAW264.7 cells into osteoclast-like cells.3 Mimics BMP4 in supporting self renewal of embryonic stem cells.4

References/Citations
1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489
2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686
3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366
4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027

Focus Biomolecules cell signaling reagent supplier, chemical structure of PD-98059 | MEK inhibitor | CAS 167869-21-8

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