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| Cat. Number | 10-2147 |
| Chemical Name | 10-2147 N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine 231277-92-2 |
| CAS Number | 231277-92-2 |
| Mol. Formula | C29H26ClFN4O4S |
| Mol. Weight | 581.06 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | Yellow solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | GW-572016 |
| Solubility | Soluble in DMSO (up to 200 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| References | Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1 Clinically useful agent for treatment of breast cancer.2-3 Cell permeable References/Citations
1) Wood et al. (2004), A unique structure for epidermal growth fsctor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells; Cancer Res., 64 6652
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