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Cat. Number
10-2139
Chemical Name
10-2139 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 446-72-0
CAS Number
446-72-0
Mol. Formula
C15H10O5
Mol. Weight
270.24
Qty 1
100mg
Qty 2
500mg
Appearance
Yellow solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
4’,5,7-Trihydroxyisoflavone
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 4 mg/ml)
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
References

Genistein (446-72-0) is a naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2 Phytoestrogen3 and agonist at GPR304. Displays cancer chemopreventive activity.5

References/Citations

1) Akiyama et al. (1987), Genistein, a specific inhibitor of tyrosine-specific protein kinases; J. Biol. Chem., 262 5592
2) Linassier et al. (1990), Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor if EGF receptor tyrosine kinase Biochem. Pharmacol., 39 187
3) Dang et al. (2003), Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein; J. Biol. Chem., 278 962
4) Vivacqua et al. (2006), 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30; Mol. Phamracol., 70 1414
5) Sarker and Li (2002), Mechanisms of cancer chemoprevention by soy isoflavone genistein; Cancer Metastasis Rev., 21 265

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