您的位置:首页>>生化试剂>>小分子化合物>>10-2138 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride 162359-56-0
Cat. Number
10-2138
Chemical Name
10-2138 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride 162359-56-0
CAS Number
162359-56-0
Mol. Formula
C19H33NO2 HCl
Mol. Weight
343.94
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Fingolimod
Solubility
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory T cell proliferation in vitro and in vivo.2 FTY720 HCl enhances microvascular remodeling via expansion of arterioles and capillary networks.3 Potent immunomodulator.4

References/Citations
1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453
2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751
3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA,110 13785
4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308

Focus Biomolecules supplier, chemical structure of FTY720 HCl | Sphingosine-1-phosphate receptor agonist | CAS 162359-56-0

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