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| Cat. Number | 10-2135 |
| Chemical Name | 10-2135 厄洛替尼·HCl Erlotinib · HCl 183319-69-9 |
| CAS Number | 183319-69-9 |
| Mol. Formula | C22H23N3O4 HCl |
| Mol. Weight | 429.91 |
| Qty 1 |
10mg |
| Qty 2 | 100mg |
| Appearance | White or off-white solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride |
| Solubility | Soluble in DMSO (up to 18 mg/ml with warming). |
| Storage condition | -20℃ |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References | Erlotinib HCl (182219-93-9) is a potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM).1 Potent inhibitor of mutant JAK2-V617F.2 Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM).3 HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells.4 A clinically effective agent for NSCLC.5 References/Citations
1) Moyer et al. (1997), Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor tyrosine kinases; Cancer Res., 57 4838
厄洛替尼·HCl 英文名称Erlotinib · HCl，货号10-2135 上海惠诚提供10mg 100mg 厄洛替尼·HCl Erlotinib · HCl，美国focus原装进口，咨询电话021-60498804 |
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