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| Cat. Number | 10-2132 |
| Chemical Name | 10-2132 Enzastaurin 170364-57-5 |
| CAS Number | 170364-57-5 |
| Mol. Formula | C32H29N5O2 |
| Mol. Weight | 515.61 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Orange solid |
| Application Notes | 98% by HPLC NMR (Conforms) |
| Synonym | LY-317615,3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
| Solubility | Soluble in DMSO (up to 7 mg/ml with warming) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| References | Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates amphetamine-stimulated dopamine efflux.4Inhibits blood-brain barrier leakiness in a mouse model.5 References/Citations
1) Graff et al. (2005), The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts; Cancer Res. 65 7462
Enzastaurin ，货号10-2132 上海惠诚提供5mg 25mg Enzastaurin，美国focus原装进口，咨询电话021-60498804 |
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