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| Cat. Number | 10-2129 |
| Chemical Name | 10-2129 多韦替尼 Dovitinib 405169-16-6 |
| CAS Number | 405169-16-6 |
| Mol. Formula | C21H21FN6O |
| Mol. Weight | 392.43 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Yellow-green solid |
| Application Notes | 99% by TLC 99% by HPLC |
| Synonym | TKI-258, CHIR258,4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Storage condition | -20℃ |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References | Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Dovitinib selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
References/Citations
多韦替尼 英文名称Dovitinib，货号10-2129 上海惠诚提供5mg 25mg 多韦替尼 Dovitinib，美国focus原装进口，咨询电话021-60498804 |
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