服务热线
021-60498804
| Cat. Number | 10-2128 |
| Chemical Name | 10-2128 Doramapimod 285983-48-4 |
| CAS Number | 285983-48-4 |
| Mol. Formula | C31H37N5O3 |
| Mol. Weight | 527.66 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White or off-white solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | BIRB-796,1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea |
| Solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml). |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| References | Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable. References/Citations
1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
Doramapimod ，货号10-2128 上海惠诚提供5mg 25mg Doramapimod，美国focus原装进口，咨询电话021-60498804 |
下一个：多韦替尼 Dovitinib上一个：CI-994 |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
