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| Cat. Number | 10-2118 |
| Chemical Name | 10-2118 阿西替尼 Axitinib 319460-85-0 |
| CAS Number | 319460-85-0 |
| Mol. Formula | C22H18N4OS |
| Mol. Weight | 386.47 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | White solid |
| Application Notes | 99% by HPLC NMR (Conforms) |
| Synonym | N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide |
| Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| References | Axitinib (319460-85-0) is a potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib is a clinically useful anticancer agent.4 References/Citations
1) Hu-Lowe et al. (2008), Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1,2,3; Cancer Res., 14 7272
阿西替尼 英文名称Axitinib ，货号10-2118上海惠诚提供10mg 50mg 阿西替尼 Axitinib，美国focus原装进口，咨询电话021-60498804 阿西替尼 英文名称Axitinib ，货号10-2118上海惠诚提供10mg 50mg 阿西替尼 Axitinib，美国focus原装进口，咨询电话021-60498804
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