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| Cat. Number | 10-2114 |
| Chemical Name | Withaferin A |
| CAS Number | 5119-48-2 |
| Mol. Formula | C28H38O6 |
| Mol. Weight | 470.60 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White solid |
| Application Notes | 99% by HPLC NMR (Conforms) |
| Synonym | (4β, 5β, 6β, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone |
| Solubility | Soluble in DMSO (up to 20 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| References | Displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5 References/Citations
1) Mohan et al. (2004), Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115
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