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| Cat. Number | 10-2102 |
| Chemical Name | 根赤壳菌素 Radiciol |
| CAS Number | 12772-57-5 |
| Mol. Formula | C18H17ClO6 |
| Mol. Weight | 364.78 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White solid |
| Application Notes | 99% by HPLC NMR (Conforms) |
| Synonym | Monorden,(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 8 mg/ml). |
| Storage condition | -20℃ |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| References | Radicicol (12772-57-5) inhibits heat shock protein 90 (HSP90) activity by binding to the ATP-binding pocket.1 In cells HSP90 client proteins such as Raf kinase2, HIF-1α3and estrogen receptor4 are destabilized and proteolytically degraded. Radicicol inhibits expression of COX-2 without affecting COX-1 expression in LPS-stimulated macrophages (IC50=27 nM).5 Inhibits angiogenesis.6 References/Citations
1) Schulte et al. (1999), Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones; Mol. Endocrinol., 13 1435
根赤壳菌素 英文名称Radiciol ，货号10-2102 上海惠诚提供1mg 5mg 根赤壳菌素 Radiciol，美国focus原装进口，咨询电话021-60498804 |
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