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/ Products Classification 点击展开+Cat. Number | 10-1617 |
Chemical Name | RI-1 |
CAS Number | 415713-60-9 |
Mol. Formula | C14H11Cl3N2O3 |
Mol. Weight | 361.61 |
Qty 1 |
5mg |
Qty 2 | 25mg |
Appearance | Yellow solid |
Application Notes | 98% by TLC NMR (Conforms) |
Synonym | 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione |
Solubility | Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming) |
Storage condition | -20°C (des.) |
Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
References | RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4. References/Citations
1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377
RI-1 ,货号10-1617上海惠诚提供10mg 50mg RI-1,美国focus原装进口,咨询电话021-60498804 |