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Cat. Number
10-1617
Chemical Name
RI-1
CAS Number
415713-60-9
Mol. Formula
C14H11Cl3N2O3
Mol. Weight
361.61
Qty 1
5mg
Qty 2
25mg
Appearance
Yellow solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Solubility
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
References

RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.

References/Citations

1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 
2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347
3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604
4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665

RI-1 | 415713-60-9 | Structure | Supplier

RI-1 ,货号10-1617上海惠诚提供10mg 50mg RI-1,美国focus原装进口,咨询电话021-60498804

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