您的位置:首页>>生化试剂>>小分子化合物>>SR-9009
Cat. Number
10-1511
Chemical Name
SR-9009
CAS Number
1379686-30-2
Mol. Formula
C20H24CLN3O4S HCl
Mol. Weight
474.4
Qty 1
5mg
Qty 2
25mg
Appearance
Tan solid
Application Notes
98% by TLC
Synonym
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Solubility
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
References

SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses atherosclerosis in a mouse model3.  Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues.4 Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.5

References/Citations
1) Solt et al. (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists; Nature, 485 62
2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249
3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem. Biophys. Res. Commun., 460 566
4) Sulli et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence; Nature, 553 351
5) Das et al. (2018) Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain; Gene 655 1

Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2

SR-9009 ,货号10-1511上海惠诚提供5mg 25mg SR-9009,美国focus原装进口,咨询电话021-60498804

下一个:U-73343上一个:STF-083010
在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们