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| Cat. Number | 10-1510 |
| Chemical Name | STF-083010 |
| CAS Number | 307543-71-1 |
| Mol. Formula | C15H11NO3S2 |
| Mol. Weight | 317.39 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Yellow solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Storage condition | RT (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References | STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. STF-083010 induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo.
References/Citations
STF-083010 ，货号10-1510 上海惠诚提供5mg 25mg STF-083010e，美国focus原装进口，咨询电话021-60498804 |
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