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Cat. Number
10-1468
Chemical Name
SC-79
CAS Number
305834-79-1
Mol. Formula
C17H17ClN2O5
Mol. Weight
364.79
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
2-Amino-6-chloro-_-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Solubility
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
References

Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.1 A useful tool for studying the PI3K/Akt axis.2 

References/Citations
1) Jo et al. (2012), Small-molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death; Proc. Natl. Acad. Sci. USA, 109 10581
2) Yang et al. (2016), MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt; Cell. Physiol. Biochem. 38 2366
3) Chen et al. (2017), Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head; Oncotarget, 8 31065

Focus Biomolecules cell signaling reagent supplier, chemical structure of SC-79 | AKT activator | CAS 305834-79-1

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