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| Cat. Number | 10-1465 |
| Chemical Name | LH-846 |
| CAS Number | 639052-78-1 |
| Mol. Formula | C16H13ClN2OS |
| Mol. Weight | 316.81 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneaceramide |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming). |
| Storage condition | RT (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| References | LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1 References/Citations 1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608
LH-846 ，货号10-1011 上海惠诚提供5mg 25mg LH-846，美国focus原装进口，咨询电话021-60498804 |
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