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Cat. Number
10-1452
Chemical Name
H2L5186303
CAS Number
139262-76-3
Mol. Formula
C26H202O8
Mol. Weight
488.45
Qty 1
5mg
Qty 2
25mg
Appearance
Yellow solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid]
Solubility
Soluble in DMSO (up to 50 mg/ml).
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
References

H2L5186303 (139262-76-3) is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist.  IC50 = 8.9 nM, 1230 nM and 27.35 μM for LPA2, LPA3, and LPA1 respectively.1,2

References/Citations

1) Fells et al. (2008) Identification of non-lipid LPA3 antagonists by virtual screening; Bioorg. Med. Chem. 16 6207
2) Fells et al. (2009) Structure-based drug design identifies novel LPA3 antagonists; Bioorg .Med. Chem. 17 7457

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