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Cat. Number
10-1427
Chemical Name
Dynasore
CAS Number
304448-55-3
Mol. Formula
C18H14N2O4
Mol. Weight
322.32
Qty 1
5mg
Qty 2
25mg
Appearance
Beige solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Solubility
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
References

Dynasore (304448-55-3) is a noncompetitive inhibitor of dynamin GTPase activity and blocks dynamin-dependent endocytosis in cells, including neurons. It inhibits the GTPase activity of dynamin1, dynamin2, and Drp1 (mitochondrial dynamin). It is cell permeable, fast acting (seconds) and reversible.1,2 Dynasore is a extremely useful tool for studying endocytosis and other cellular events which are dependent on dynamin.3-5

References/Citations
1) Macia et al. (2006), Dynasore, a cell-permeable inhibitor of dynamin; Dev. Cell, 10 839
2) Kirschhausen et al. (2008), Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis; Methods Enzymol., 438 77
3) Lu et al. (2009), Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons; J. Biol. Chem., 284 1930
4) Chung et al. (2010), Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission; J. Neurosci., 30 1363
5) Poirer et al. (2009), Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route; J. Biol. Chem., 284 28856

Focus Biomolecules cell signaling reagent supplier, chemical structure of Dynasore | Dynamin inhibitor |  CAS 304448-55-3

Dynasore ,货号10-1427 上海惠诚提供5mg 25mg Dynasore,美国focus原装进口,咨询电话021-60498804
Dynasore ,货号10-1427 上海惠诚提供5mg 25mg Dynasore,美国focus原装进口,咨询电话021-60498804
 
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