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| Cat. Number | 10-1412 |
| Chemical Name | Importazole |
| CAS Number | 662163-81-7 |
| Mol. Formula | C20H22N4 |
| Mol. Weight | 318.43 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Off-white solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | IPZ,N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine |
| Solubility | Soluble in DMSO (up to 10 mg/ml). |
| Storage condition | RT |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| References | Importazole (662163-81-7) specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.1 When added to cells during mitosis, importazole impairs the release of an importin-β cargo probe and causes defects in spindle assembly. Disrupts proteostasis and triggers infolded protein response-mediated apoptosis.5 Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. Importazole is an important new tool to probe the function of the importin-β/RanGTP pathway.2-4 Cell permeable.
References/Citations
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