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Cat. Number
10-1379
Chemical Name
羟基氯喹硫酸盐 Hydroxychloroquine sulfate
CAS Number
747-36-4
Mol. Formula
C18H26ClN3O H2SO4
Mol. Weight
433.96
Qty 1
50mg
Qty 2
250mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinolone sulfate
Solubility
Soluble in Water (up to 40 mg/ml).
Storage condition
RT (des.)
Stability
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
References

Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy.3 Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells.4 Hydroxychloroquine sulfate has been used to treat alopecia successfully5 and is a clinically useful antimalaria agent. Cell permeable and active in vivo.

References/Citations
1) Boya et al. (2005), Inhibition of macroautophagy triggers apoptosis; Mol. Cell Biol., 25 1025
2) Xie et al. (2013), Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma; PLoS One, 8 e55096
3) Pan et al. (2011), Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy; Clin. Cancer Res., 150 3248
4) Jeong et al. (2002), Chloroquine decreases cell-surface expression of tumor necrosis factor receptors in human histiocytic U-937 cells; Immunology, 105 83
5) Stephan et al. (2013), Successful treatment of alopecia totalis wih hydroxychloroquine: report of 2 cases; J. Am. Acad. Dermatol., 68 1048

Focus Biomolecules supplier, chemical structure of Hydroxychloroquine sulfate | Autophagy inhibitor | CAS 747-36-4

羟基氯喹硫酸盐  英文名称Hydroxychloroquine sulfate ,货号10-1379 上海惠诚提供250mg 50mg 羟基氯喹硫酸盐 Hydroxychloroquine sulfate,美国focus原装进口,咨询电话021-60498804

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