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Cat. Number
10-1336
Chemical Name
Sirtinol
CAS Number
410536-97-9
Mol. Formula
C26H22N2O2
Mol. Weight
394.48
Qty 1
5mg
Qty 2
25mg
Appearance
Pale yellow solid
Application Notes
98% NMR (Conforms)
Synonym
2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Solubility
Soluble in DMSO (up to 30 mg/ml).
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
References

Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in purified enzyme studies. Cell permeable.

References/Citations
1) Ota et al. (2006) SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells; Oncogene, 25 176
2) Mai et al. (2005) Design, synthesis and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors; J. Med. Chem. 48 7789
3) Grozinger et al. (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening; J. Biol. Chem. 276 38837
4) Koering et al. (2002) Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity; EMBO Rep. 3 1055

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