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Cat. Number
10-1310
Chemical Name
GSK-690693 HCl
CAS Number
937174-76-0
Mol. Formula
C21H27N7O3 HCl
Mol. Weight
461.96
Qty 1
5mg
Qty 2
25mg
Appearance
Off-white solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridine-4-yl)-2-methylbut-3-yn-2-ol HCl
Solubility
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 30 mg/ml).
Storage condition
-20°C (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
References

GSK-690693 (937174-76-0) is a novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50's=2, 13, 9 nM for Akt1, 2 and 3 respectively) Antitumor activity. Active in vivo. GSK-690693 induces hyperglycemia. Cell permeable.

References/Citations
1) Rhodes et al. (2008), Characterization of an Akt kinase inhibitor with potent pharmacodynamics and antitumor activity; Cancer Res., 68 2366
2) Crouthamel et al. (2009), Mechanism and management of AKT inhibitor-induced hyperglycemia; Clin. Cancer Res., 15 217

Focus Biomolecules cell signaling reagent supplier, chemical structure GSK-690693 HCl | AKT inhibitor | CAS 937174-76-0

GSK-690693 HCl,货号10-1310 上海惠诚提供10mg 50mg GSK-690693 HCl,美国focus原装进口,咨询电话021-60498804
GSK-690693 HCl,货号10-1310 上海惠诚提供10mg 50mg GSK-690693 HCl,美国focus原装进口,咨询电话021-60498804
 
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