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Cat. Number
10-1296
Chemical Name
BAY 11-7082
CAS Number
19542-67-7
Mol. Formula
C10H9NO2S
Mol. Weight
207.27
Qty 1
10mg
Qty 2
50mg
Appearance
Off-white solid
Application Notes
98% by TLC
Synonym
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage condition
RT
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive IκB-α phosphorylation.1 The effects on adhesion molecule expression were found to be irreversible.

References/Citations
1) Pierce et al. (1997) Novel inhibitor of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J. Biol. Chem. 272 21096

Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7

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