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| Cat. Number | 10-1287 |
| Chemical Name | SMER28 |
| CAS Number | 307538-42-7 |
| Mol. Formula | C11H10BrN3 |
| Mol. Weight | 264.12 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Beige solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 6-Bromo-4-allylaminoquinazoline |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 2 mg/ml) |
| Storage condition | RT (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| References | Induces autophagy via an mTOR-independent pathway. Enhances clearance of b-amyloid protein in cell lines and primary neuronal culture models.1-3 May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4 Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5 Promotes reprogramming of fibroblasts to neural stem-like cells.6 Cell permeable. References/Citations
1) Tian et al. (2011), A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway; FASEB J., 25 1934
SMER28 ，货号10-1287 上海惠诚提供5mg 25mg SMER28，美国focus原装进口，咨询电话021-60498804 |
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