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| Cat. Number | 10-1283 |
| Chemical Name | Trifluorothymidine |
| CAS Number | 70-00-8 |
| Mol. Formula | C10H11F3N2O5 |
| Mol. Weight | 296.20 |
| Qty 1 |
50mg |
| Qty 2 | 250mg |
| Appearance | Off-white solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 2’-Deoxy-5-trifluoromethyluridine,α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFT |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| References | Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2 After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes.3 Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.4 References/Citations
1) Bijnsdorp et al. (2010), Differential activation of cell death and autophagy results in an increaded cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells; Int. J. Cancer, 126 2457
Trifluorothymidine ，货号10-1283 上海惠诚提供50mg 250mg Trifluorothymidine，美国focus原装进口，咨询电话021-60498804 |
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