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| Cat. Number | 10-1244 |
| Chemical Name | Ingenol-3-angelate |
| CAS Number | 75567-37-2 |
| Mol. Formula | C25H34O6 |
| Mol. Weight | 460.53 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | PEP-005 |
| Solubility | Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml) |
| Storage condition | -20℃ |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| References | Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated human T cells via activation of PKC and downstream activation of NFκB.2 Treatment of subcutaneous tumors results in anti-cancer CD8 T cells, also displays adjuvant activity and synergizes with cancer immunotherapies.3 Induces senescence-like growth arrest in solid tumor cells.4Inhibits HIV-1 infection at an early pathway of viral entry.5
References/Citations
1) Hampson et al. (2005), PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC; Blood, 106 1362
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