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Cat. Number
10-1222
Chemical Name
洛伐他汀 Lovastatin
CAS Number
75330-75-5
Mol. Formula
C24H36O5
Mol. Weight
404.55
Qty 1
100mg
Qty 2
500mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Mevinolin,2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage condition
-20°C
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
References

Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Lovastatin is a clinically useful antihyperlipemic agent.5 Cell permeable.

References/Citations

1) Alberts et al. (1988), Discovery, biochemistry and biology of lovastatin;  Am. J. Cardiol., 62 10J
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated;  Cell, 57 1167
3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis;  Anticancer Res., 19 3133
4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells;  Eur. J. Pharmacol., 765 415
5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin;  Am. J. Cardiol., 62 28J

Focus Biomolecules cell signaling reagent supplier, structure Lovastatin | HMG-CoA reductase inhibitor | CAS 75330-75-5

洛伐他汀  英文名称Lovastatin ,货号10-1222 上海惠诚提供100mg 500mg洛伐他汀 Lovastatin ,美国focus原装进口,咨询电话021-60498804

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