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| Cat. Number | 10-1171 |
| Chemical Name | A-769662 |
| CAS Number | 844499-71-4 |
| Mol. Formula | C20H12N2O3S |
| Mol. Weight | 360.39 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Beige solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml), |
| Storage condition | -20°C |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| References | A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM.2 A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice.2 Inhibits adipocyte differentiation.3 Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming.4 A-769662 synergizes with AICAR.5 Cell permeable. References/ A-769662 Citations
1) Scott et al. (2008), Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes; Cell Biol., 15 1220
A-769662，货号10-1171 上海惠诚提供25mg 5mg A-769662，美国focus原装进口，咨询电话021-60498804 |
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