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Cat. Number
10-1160
Chemical Name
HPA(己基-4-戊炔酸) HPA (Hexyl-4-pentynoic acid )
CAS Number
96017-59-3
Mol. Formula
C11H18O2
Mol. Weight
182.27
Qty 1
50mg
Qty 2
100mg
Appearance
Colorless oil
Application Notes
97% by TLC NMR (Conforms)
Synonym
HPA,2-(2-Propynyl)octanoic acid (racemic)
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
References

HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 μM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons2. Cell permeable.

References/Citations
1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272
2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

Focus Biomolecules cell signaling reagent supplier, chemical structure of HPA | HDAC inhibitor | CAS 96017-59-3

HPA(己基-4-戊炔酸)  英文名称HPA   (Hexyl-4-pentynoic acid ) ,货号10-1160 上海惠诚提供100mg 50mg HPA(己基-4-戊炔酸) HPA   (Hexyl-4-pentynoic acid ),美国focus原装进口,咨询电话021-60498804

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